Applying panel generalized least square (GLS) analysis to data collected from the Total Economy Database – The Conference Board, (TED-1 and TED-2, Byrane and Corrado, 2016), we investigate the driving forces in the growth of TFP. Due to data availability, we extracted TFP and ICT and non-ICT annual growth data from TED-2 for 1981 to 2015, covering most developed and developing nations. We found that the impact of ICT growth on total factor productivity (TFP) is uneven for more financially open and less financially open countries. The impact of ICT growth on TFP growth is more important in financial open economies, but ICT growth is somewhat negligible for TFP growth in less financially open countries. Trade openness had a positive impact on TFP growth for all countries. Financial openness can be measured both de facto and de jure. External liabilities have exhibited a positive impact on TFP growth but not on external assets.